workerla.blogg.se - Antidote for calcium channel blocker overdose

Some advocate a trial of lipid emulsion** therapy (not FDA-approved for indication) when insulin and other therapies seem to be failing.Some have also suggested a role for glucagon, but its benefit beyond that of standard inotropes and vasopressors is unclear. Standard goal-directed pharmacological inotropes and vasopressors, such as epinephrine, may be used if insulin therapy is insufficient.Cardiac contractility assessed by ultrasonography.

Success of therapy may be measured by assessment of perfusion.

Not a vasoconstrictor, so improvements in blood pressure may be modest.

Appears most effective if initiated early in course of poisoning illness.

High-dose insulin** therapy can increase cardiac output without increasing myocardial oxygen demand.

Goal = to improve cardiac output to maintain sufficient perfusion of vital organs. Treatment of cardiogenic shock due to calcium channel blockade*